ESTIMATION THE PHYSIOLOGICAL ROLE OF FGF21 IN OBESE WOMEN IN SAMARRA CITY

Abstract

A global health concern, obesity is associated with higher rates of morbidity and mortality. Diabetes, fatty liver, hypertension, hyperlipidemia, cardiovascular disease, and cancer are among the complex disorders that define it. Chronic energy intake and expenditure imbalances result in excess fat accumulation in adipose tissue, which is the cause of obesity. The aim of this study is to determine the FGF21 levels in obese women and its relationship to obesity and studying the relationship of FGF21 with body mass and its relationship with obesity and adipose tissue. Fortytwo women were used in this study. Women age ranges from 20-35 years and divided into two groups: control group (12 women) BMI less than 24 and obese group (30 women) BMI more than 30. Pregnant women were excluded and also women with liver diseases, ovary cyst syndrome and chronic diseases. All cases are collected from 1st December 2023 to February 2024 from Samarra city and they were in good health, were not presently taking medications, levels of Fibroblast Growth Factor 21 (FGF21) was measured using ELISA techniques, established tools and procedures used, the waist circumference (WC) and body mass index (BMI) were determined. The findings indicated a positive correlation between BMI and WC measures and a substantial (P<0.01) elevate in FGF21 levels in the obese group when compared to the group of control. ability to predict neck pain from this addiction. This study offers new therapeutic targets for the prevention and treatment of obesity, which is an epidemic that is still growing. It is evident; therefore, that FGF21 is a very promising targetable system for therapeutic management of the various metabolic issues linked to obesity.