DIFFERENCES IN ANTI-CCP EXAMINATION RESULTS IN MOTORBIKE TAXI DRIVERS WITH 1-3 YEARS OF WORK AND MORE THAN 3 YEARS USING THE ELISA METHOD

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease that generally causes inflammation of the joints. Most RA patients have not shown typical clinical symptoms at the beginning of the disease, so it is necessary to carry out laboratory tests such as anti-CCP. Anti-CCP is synthesized as a result of an immune response against joint proteins which are citrulinated in the post-translation. The cause of the autoantigen process is not known for certain, it is strongly suspected due to foreign agents such as viruses and bacteria. This condition is very vulnerable for motorcycle taxi drivers who can spend 8-12 hours on the road. Motorcycle taxi drivers are very at risk of being exposed to various pollutant materials such as dust, gas, and microorganisms, either bacteria or viruses. Motorcycle taxi drivers with longer working periods, will increase anti-CCP levels, due to amount of concentration and length of time exposed by pollutant materials is higher. The working period is divided into 2 categories, namely new workers with 3 years of service and old workers with > 3 years of service. The purpose of this study is to determine the differences of anti-CCP test results in motorcycle taxi driver with 1-3 years service and more than 3 years service using ELISA method. The number of samples is 20 people who are motorcycle taxi drivers in Kedungmundu District taken using a consecutive sampling technique. The results shown that the average anti-CCP value for motorcycle taxi drivers with 1-3 years of service was 2,409 ng/ml, while > 3 years of service was 4,994 ng/ml. Independent t-test shown a significance value of 0.000 (P<0.05), which means there is a significant difference between the results of anti-CCP examinations for motorcycle taxi drivers with 1-3 years of service and more than 3 years.